AAPS Microdialysis Focus Group Steering Committee 2 Goals & Objectives Microdialysis Technique
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SPECIAL MESSAGE The Microdialysis Focus Group shares the grief of the lives lost at the Sandy Hook School tragedy in Newtown, CT. With Probes magazine, we are spreading the light of knowledge.
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Critical evaluation of colon submucosal microdialysis in awake, mobile rats
Sensors able to record large bowel physiology and biochemistry in situ in awake rodents are lacking. Microdialysis is a mini-invasive technique that may be utilized to continuously deliver or recover low-molecular substances from various tissues. In this experiment we evaluated the feasibility of in vivo microdialysis to monitor extracellular fluid chemistry in the descending colon submucosa of...
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In the present study, the effect of steroidal anti-inflammatory drug betamethasone (0.12, 0.24 mg/kg, i.p. acutely) on striatal glutamate level in Parkinsonian rats was studied using the microdialysis technique. Our results showed significant differences (p
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In this study we describe, to our knowledge, the first experiment using the microdialysis technique for studying the release of prostaglandin E 2 (PGE 2 ) in the proximal tibia metaphysis secondary to mechanical loading. Nine healthy females, six in the loading group and three controls, mean age 34 6 2 (years 6 SEM), participated. A standard microdialysis catheter was inserted into the tibia me...
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Penciclovir is a drug active against herpes simplex viruses located in the epidermis basal layer. The aim of this study was to compare the suction blister technique and microdialysis as methods to measure the penciclovir concentration in the skin after a single dose (250 mg) of its prodrug, famciclovir. Suction blister fluid, microdialysates and plasma were sampled from 11 healthy volunteers fo...
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BACKGROUND AND PURPOSE We sought (1) to identify early metabolic markers for the development of (ir)reversible neurological deficits and cerebral infarction in subarachnoid hemorrhage (SAH) patients by using the microdialysis technique and (2) to evaluate the influence of intracerebral hemorrhage (ICH) on microdialysis parameters. METHODS We performed a prospective study of 44 SAH patients wi...
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